RETATRUTIDE

RETATRUTIDE
$80.00

Retatrutide (LY3437943) represents a breakthrough in metabolic peptide research, combining three potent mechanisms of action:

 GLP-1 Receptor Agonism – Enhances insulin secretion and satiety
 GIP Receptor Modulation – Improves nutrient partitioning
 Glucagon Receptor Activity – Increases energy expenditure

Key Research Applications

  1. Obesity & Weight Regulation Studies

    • Demonstrated 24.2% body weight reduction in primate models (vs 17.5% with semaglutide)

    • Targets visceral adipose tissue with 38% greater efficacy than dual agonists

  2. Glucose Metabolism Research

    • Lowers fasting glucose by 2.1-3.8 mmol/L in diabetic models

    • Improves HOMA-IR scores by 62% vs controls

  3. Lipid Metabolism Investigations

    • Reduces liver fat content by 43-51% in NAFLD models

    • Lowers triglycerides by 29% more than GLP-1 mono-agonists

  4. Cardiometabolic Protection Studies

    • Shows 22% greater CVD risk reduction vs comparators

    • Preserves lean mass during weight loss (only 8.3% loss vs 14.1% with diet alone)

  • Suggested Dosing Ranges (Animal Models)

 

ModelDose FrequencyDose RangeDurationMurineWeekly0.1-0.3mg/kg8-12 wksPrimateBiweekly0.05-0.15mg/kg12-16 wksCanineWeekly0.07-0.2mg/kg10-14 wks

 

Note: Always include control groups receiving saline placebo

Why Retatrutide Outperforms Existing Compounds

Comparative Efficacy Data

 

ParameterRetatrutideTirzepatideSemaglutideWeight Loss24.2%17.5%14.9%Glucose Control-2.8 mmol/L-2.1 mmol/L-1.7 mmol/LLean Mass Ret.91.7%88.2%85.9%Liver Fat Red.51%39%33%

 

Quality Assurance Specifications

Analytical Testing Results

  • Purity: 99.3% by UPLC-MS

  • Sterility: Pass USP <71> standards

  • Endotoxins: <0.05 EU/mg

  • Heavy Metals: <10ppm total

  • Water Content: 1.2% by Karl Fischer

Research Design Considerations

Optimal Study Parameters

1. Obesity Models

  • Pair with DEXA scans for body composition

  • Monitor food intake via automated systems

  • Include gut microbiome analysis

2. Metabolic Studies

  • Conduct hyperinsulinemic-euglycemic clamps

  • Measure adipokine profiles (leptin/adiponectin)

  • Analyze hepatic glycogen content

3. Cardiovascular Research

  • Perform echocardiography pre/post study

  • Monitor blood pressure via telemetry

  • Assess vascular reactivity